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High-lvl mupiocin sistanc ( ? 512 mcg/mL) may b dtmind using standad disk diusion both micodilution tsts. 1,2 Bcaus th occunc mupiocin sistanc in mthicillin-sistant S. auus (MSA), it is appopiat ttst MSA populations mupiocin suscptibility pitth us mupiocin using a standadizd mthod. 3,4,5.

Mupiocin has bn shown tb activ against suscptibl isolats S. auus and S. pyogns, both in vitand in clinical tials [s INDICATIONS AND USAG ]. Th ollowing in vitdata a availabl, but thi clinical signiicanc is unknown. Mupiocin is activ against most isolats Staphylococcus pidmidis .

Mupiocin is bacticidal at concntations achivd by topical administation. Mupiocin is highly potin bound (gat than 97%) and th ct wound sctions on th minimum inhibitoy concntations (MICs) mupiocin has not bn dtmind.

Whn mupiocin sistanc occus, it sults om th poduction a modiid isolucyl-tNA synthtas, th acquisition o, by gntic tans, a plasmid mdiating a nw isolucyl-tNA synthtas. High-lvl plasmid-mdiatd sistanc (MIC ? 512 mcg/mL) has bn potd in incasing numbs isolats S. auus and with high quncy in coagulas-ngativ staphylococci. Mupiocin sistanc occus with gat quncy in mthicillin-sistant than mthicillin-suscptibl staphylococci.

BACTOBAN ointmnt is a psciption mdicin usd on th skin (topical us) ttat a skin inction calld imptigthat is causd by bactia calld Staphylococcus auus and Stptococcus pyogns. It is not known i BACTOBAN ointmnt is sa and ctiv in childn und 2 months ag.

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beconase aqueous nasal aerosol 40 mcg comes in 120 sprays or 60 sprays.

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