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For children from 5 to 12 years, the maximum allowable daily dosage of motilium is 2.

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Along with their useful effectsmost medicines can cause unwanted side-effects although not everyone experiences themThe table below contains some of the most common ones associated with domperidoneYou will find a full list in the manufacturer’s information leaflet supplied with your medicineSpeak with your doctor or pharmacist if any of the following become troublesome.

For the short term treatment in adults of1Symptoms associated with idiopathic or diabetic gastroparesis(once control of diabetes has been established by diet and/or insulinattempt should be made to discontinue MOTILIUM2Intractable nausea and vomiting from any cause.

Domperidone is a dopamine antagonist with antiemetic propertiesIt should no longer be sold to anyone without a prescriptionIt is associated with a small increased risk of serious cardiac side effectsegQTc prolongationtorsade de pointesserious ventricular arrhythmiaand sudden cardiac deathTherefore people need to have a medical assessment before taking domperidone to determine if it is suitable for them.

Domperidone is a peripheral dopamine D 2receptor antagonist with gastrokinetic and anti-emetic propertiesIt is used in the treatment of symptoms of nausea and vomiting of variable originIt exerts its actions via inhibition of dopamine receptors in the human gutand in the chemoreceptor trigger zoneCTZwhich lies outside the blood-brain barrier in the area postremaThe active substance is available as domperidone and as domperidone maleate.

Separate in vivo pharmacokinetic/pharmacodynamic interaction studies with oral ketoconazole or oral erythromycin in healthy subjects confirmed a marked inhibition of domperidone’s CYP3A4 mediated first pass metabolism by these drugs.

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