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The film-coated tablets are peach tablets of biconvex, oblong shape with the marking 500 on the one side and xeloda on the other side.

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SeeWhat are the possible side effects of XELODAfor more information about side effects.

SeeWhat are the possible side effects of XELODAfor more information about side effects.

Physicians should exercise caution in monitoring the effects of XELODA in the elderlyInsufficient data are available to provide a dosage recommendation.

The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorinDeaths from severe enterocolitisdiarrheaand dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil.

Enzymes convert capecitabine to 5-fluorouracil5-FUin vivoBoth normal and tumor cells metabolize 5-FU to 5-fluoro-2deoxyuridine monophosphateFdUMPand 5-fluorouridine triphosphateFUTPThese metabolites cause cell injury by two different mechanismsFirstFdUMP and the folate cofactorNmethylenetetrahydrofolatebind to thymidylate synthaseTSto form a covalently bound ternary complexThis binding inhibits the formation of thymidylate from 2deoxyuridylateThymidylate is the necessary precursor of thymidine triphosphatewhich is essential for the synthesis of DNAso that a deficiency of this compound can inhibit cell divisionSecondnuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphateUTPduring the synthesis of RNAThis metabolic error can interfere with RNA processing and protein synthesis.

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