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Decreased metabolism of olanzapine may lead to clinically important adverse reactions, such as orthostatic hypotension, sedation, or extrapyramidal symptoms.

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NMS is a potentially life-threatening condition associated with antipsychotic medicinal productsRare cases reported as NMS have also been received in association with olanzapineClinical manifestations of NMS are hyperpyrexiamuscle rigidityaltered mental statusand evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresisand cardiac dysrhythmiaAdditional signs may include elevated creatine phosphokinasemyoglobinuriarhabdomyolysisand acute renal failureIf a patient develops signs and symptoms indicative of NMSor presents with unexplained high fever without additional clinical manifestations of NMSall antipsychotic medicinesincluding olanzapine must be discontinued.

Olanzapine can be given without regards for meals as absorption is not affected by foodGradual tapering of the dose should be considered when discontinuing olanzapine.

Increased potentialin adolescents as compared with adultsfor weight gain and hyperlipidemiaclinicians prescribing to adolescents should consider potential long-term riskswhich in many cases may lead them to prescription of other drugs first in this population.

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in placebo-controlled trials, there was a significantly higher incidence of cerebrovascular adverse events in patients treated with oral olanzapine compared to patients treated with placebo.

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