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Digoxin dih jox inn or lanoxin lan-ox-in is a medicine that makes the heart work more efficiently.

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Avoid becoming overheated or dehydrated during exercisein hot weatheror by not drinking enough fluidsDigoxin overdose can occur more easily if you are dehydrated.

Digoxin is primarily excreted by the kidneysthereforepatients with impaired renal function require smaller than usual maintenance doses of digoxinsee DOSAGE AND ADMINISTRATIONBecause of the prolonged elimination half-lifea longer period of time is required to achieve an initial or new steady-state serum concentration in patients with renal impairment than in patients with normal renal functionIf appropriate care is not taken to reduce the dose of digoxinsuch patients are at high risk for toxicityand toxic effects will last longer in such patients than in patients with normal renal function.

Patients with Wolff-Parkinson-White syndrome who develop atrial fibrillation are at high risk of ventricular fibrillationTreatment of these patients with digoxin leads to greater slowing of conduction in the atrioventricular node than in accessory pathwaysand the risks of rapid ventricular response leading to ventricular fibrillation are thereby increased.

ClinicalAdvisor.com is for nurse practitioners and physician assistantsoffering the latest information on diagnosingtreatingmanagingand preventing medical conditions typically seen in the office-based primary-care setting.

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the digoxin auc value was reduced approximately 50 in cancer patients who received digoxin lanoxin tablets with high dose chemotherapy in a pharmacokinetic study n 6 .

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