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Based on the mechanism of action of snris and ssris, including paroxetine hydrochloride, and the potential for serotonin syndrome, caution is advised when paxil is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, lithium, fentanyl, tramadol, amphetamines, or st.

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Certain medicines to treat narcolepsy or ADHDamphetamineatomoxetinedextroamphetamineAdderallDexedrineEvekeoVyvanseand others;

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Compounds of structure2are prepared by reaction of an arecoline analogue of structure(4with an organometallic compound containing an X-substituted phenyl groupsuch as a compound of structure3STR1Suitably the compound of structure3is a Grignard reagentwhere M is magnesium and Y is a halogen atomor M may be a Group II metal and Y is a halogen atom or a second X-substituted phenyl groupWhen structure3is a Grignard reagentthe reaction is carried out either in a suitable non-ether solventtypically a hydrocarbon or a non-reactive chlorinated hydrocarbonor in a mixture of such a solvent with diethyl etherCompounds of structure2are important intermediates in the preparation of inter alia paroxetine.

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if skb had been sincere in detecting any paxil inducement of physical and or psychological dependency, skb would have set up a systematic monitoring program for the placebo group.

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