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Methotrexate can cause serious or life-threatening side effectsTell your doctor if you have diarrheamouth sorescoughshortness of breathupper stomach paindark urinenumbness or tinglingmuscle weaknessconfusionseizureor skin rash that spreads and causes blistering and peeling.

The good newsThese side effects can often be short-circuited by taking a folic acid supplementFolic acid is the synthetic form of folateOne study found that RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent.

DrRanganathan recommends taking 1 mg of folic acid dailythough for convenience some other physicians instruct patients to pop a single 5 mg dose once a weekSome doctors recommend taking folic acid 24 hours after receiving a dose of methotrexateask your physician for complete instructions on using folic acid supplements

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also, altered protein binding may have occurred; both dantrolene and methotrexate bind to albumin.

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