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Neuromuscular Blocking AgentsClinical data and animal studies suggest that verapamil may potentiate the activity of neuromuscular blocking agentscurare-like and depolarizingIt may be necessary to decrease the dose of verapamil and/or the dose of the neuromuscular blocking agent when the drugs are used concomitantly.

Electrical activity through the AV node dependsto a significant degreeupon calcium influx through the slow channelBy decreasing the influx of calciumISOPTIN prolongs the effective refractory period within the AV node and slows AV conduction in a rate related manner.

This medication passes into breast milkbut is unlikely to harm a nursing infantConsult your doctor before breast-feeding.

RifampinTherapy with rifampin may markedly reduce oral verapamil bioavailability.

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