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Due to the occasional occurrence of drowsinesspatients should be alerted to the need for due precaution when engaging in activities where alertness is mandatory.

A fluid intake sufficient to yield a daily urinary output of at least 2 liters and the maintenance of a neutral orpreferablyslightly alkaline urine are desirable to1avoid the theoretical possibility of formation of xanthine calculi under the influence of therapy with Zyloprim and2help prevent renal precipitation of urates in patients receiving concomitant uricosuric agents.

Zyloprim can substantially reduce serum and urinary uric acid levels in previously refractory patients even in the presence of renal damage serious enough to render uricosuric drugs virtually ineffectiveSalicylates may be given conjointly for their antirheumatic effect without compromising the action of ZyloprimThis is in contrast to the nullifying effect of salicylates on uricosuric drugs.

Many medications can cause side effectsA side effect is an unwanted response to a medication when it is taken in normal dosesSide effects can be mild or severetemporary or permanent.

Hypersensitivity syndromeA severe allergic reaction called hypersensitivity syndrome has occurred for some people with the use of allopurinolThis reaction involves a number of organs in the body and may be fatal if not treated quicklyStop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reactionincluding feverswollen glandsyellowing of the skin or eyesor flu-like symptoms with skin rash or blistering.

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