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Because cross-reactivity between aspirin and other nsaids has been reported in such aspirin-sensitive patients, indocin is contraindicated in patients with this form of aspirin sensitivity see contraindications .

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If you are taking indomethacin on a regular scheduletake the missed dose as soon as you rememberHoweverif it is almost time for the next doseskip the missed dose and take only the next regularly scheduled doseDo not take a double dose.

NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneysThe impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failureand use of NSAIDs in these patients should be done cautiouslyIndividuals who have nasal polyps or are allergic to aspirin or other NSAIDs should not use indomethacin because there is an increased risk of severe allergic reactions in these individuals.

Tell your doctor right away if any of these unlikely but serious side effects occurhearing changessuch as ringing in the earsmental/mood changesdifficult/painful swallowingsymptoms of heart failuresuch as swelling ankles/feetunusual tirednessunusual/sudden weight gain

Angiotensin-converting enzymeACEinhibitors angiotensin II receptor blockers water pillsdiureticssuch as hydrochlorothiazide.

When indomethacin is used in combination with methotrexateRheumatrexTrexallor aminoglycosidesfor examplegentamicinthe blood levels of the methotrexate or aminoglycoside may increasepresumably because their elimination from the body is reducedThis may lead to more methotrexate or aminoglycoside-related side effects.

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correct volume status in dehydrated or hypovolemic patients prior to initiating indocin.

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