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RacePharmacokinetic data revealed no significant differences between African-American and Caucasian subjects.

A migraineon the other handis also a type of a tension-type headache which results in an acute throbbing sensation in one part of your headUsuallymigraine headaches are highly painfulMigraine pain makes it difficult for a person to carry out his/her daily tasksSymptoms or signs associated with migraine attacks are:

Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome.

Current theories on the aetiology of migraine headache suggest that the symptoms are due to local cranial vasodilatation and/or to the release of vasoactive and pro-inflammatory peptides from sensory nerve endings in an activated trigeminal systemThe therapeutic activity of rizatriptan in migraine can most likely be attributed to agonist effects at 5-HT 1B/1D receptors on the extracerebralintracranial blood vesselswhich become dilated during a migraine attackand on nerve terminals in the trigeminal systemActivation of these receptors results in cranial vessel constrictioninhibition of neuropeptide release and reduced transmission in trigeminal pain pathways.

RacePharmacokinetic data revealed no significant differences between African-American and Caucasian subjects.

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