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Evista should not be used during pregnancy becoming pregnant or when lactating without doctor s advice.

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Raloxifene HCl was not genotoxic in any of the following test systemsthe Ames test for bacterial mutagenesis with and without metabolic activationthe unscheduled DNA synthesis assay in rat hepatocytesthe mouse lymphoma assay for mammalian cell mutationthe chromosomal aberration assay in Chinese hamster ovary cellsthe in vivo sister chromatid exchange assay in Chinese hamstersand the in vivo micronucleus test in mice.

There are no data available regarding the effect of EVISTA on invasive breast cancer incidence in women with inherited mutationsBRCA1BRCA2to be able to make specific recommendations on the effectiveness of EVISTAEVISTA is not indicated for the treatment of invasive breast cancer or reduction of the risk of recurrenceEVISTA is not indicated for the reduction in the risk of noninvasive breast cancer.

EVISTAraloxifene hydrochlorideis an estrogen agonist/antagonistcommonly referred to as a selective estrogen receptor modulatorSERMthat belongs to the benzothiophene class of compoundsThe chemical structure is:

Increased risk of blood clots in the legsdeep vein thrombosisand lungspulmonary embolismhave been reported with EVISTAWomen who have or have had blood clots in the legslungsor eyes should not take EVISTAWomen who have had a heart attack or are at risk for a heart attack may have an increased risk of dying from stroke when taking EVISTA.

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when you start with evista, inform the doctor if you are using medicines like cholestyramine, warfarin, or other blood thinners, diaoxide, diazepam, or using birth control pills.

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