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Antidepressant medications are used to treat a variety of conditionsincluding depression and other mental/mood disordersThese medications can help prevent suicidal thoughts/attempts and provide other important benefitsHoweverstudies have shown that a small number of peopleespecially people younger than 25who take antidepressants for any condition may experience worsening depressionother mental/mood symptomsor suicidal thoughts/attemptsThereforeit is very important to talk with the doctor about the risks and benefits of antidepressant medicationespecially for people younger than 25even if treatment is not for a mental/mood conditionTell the doctor right away if you notice worsening depression/other psychiatric conditionsunusual behavior changesincluding possible suicidal thoughts/attemptsor other mental/mood changesincluding new/worsening anxietypanic attackstrouble sleepingirritabilityhostile/angry feelingsimpulsive actionssevere restlessnessvery rapid speechBe especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

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Tricyclic antidepressantsincluding doxepinshould not be taken with any of the monoamine oxidase inhibitorMAOIclass of antidepressantsfor exampleisocarboxazidMarplanphenelzineNardiltranylcypromineParnateselegilineEldepryland procarbazineMatulaneor other drugs that inhibit monoamine oxidase such as linezolidZyvoxand intravenous methylene blueSuch combinations may lead to confusionhigh blood pressuretremorhyperactivitycomaand deathDoxepin should not be administered for at least 14 days after stopping.

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