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The combination of hydrochlorothiazide and triamterene is used to treat fluid retention edema and high blood pressure hypertension .

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MAXZIDE may be used alone or in combination with other antihypertensive drugssuch as beta-blockersSince MAXZIDEtriamterene and hydrochlorothiazidemay enhance the actions of these drugsdosage adjustments may be necessary.

For the treatment of edema associated with congestive heart failurecirrhosis of the liverand the nephrotic syndromealso in steroid-induced edemaidiopathic edemaand edema due to secondary hyperaldosteronism.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancyThiazides are indicated in pregnancy when edema is due to pathologic causesjust as they are in the absence of pregnancyDependent edema in pregnancyresulting from restriction of venous return by the expanded uterusis properly treated through elevation of the lower extremities and use of support hoseuse of diuretics to lower intravascular volume in this case is illogical and unnecessaryThere is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the motherin the absence of cardiovascular diseasebut which is associated with edemaincluding generalized edemain the majority of pregnant womenIf this edema produces discomfortincreased recumbency will often provide reliefIn rare instancesthis edema may cause extreme discomfort which is not relieved by restIn these casesa short course of diuretics may provide relief and may be appropriate.

To reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.

Tell your doctor right away if you have any serious side effectsincludingnausea/vomiting that doesn’t stopstomach/abdominal painyellowing eyes/skindark urinesigns of infectionsuch as sore throat that doesn’t go awayfeverchillscoughsigns of kidney problemssuch as pain in the side/back/abdomenpainful urinationblood in the urinechange in the amount of urinejoint painsuch as big toe paineasy bruising/bleeding.

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